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目的研究数字体相关(digital volume correlation,DVC)方法测量肺部肿瘤和胸腔随患者呼吸运动的变形及位移情况的可行性。方法利用DVC跟踪胸腔内组织三维运动的算法,通过四维CT成像技术拍摄肺癌患者一个完整的呼吸过程。以吸气开始为初始状态,确定肿瘤和胸腔位置,运用DVC软件,分析初始状态下肺部4个特征体域在20%、40%、60%、80%和100%呼吸相位下以及胸腔上4个特征体域在100%呼吸相位下的三维位移值。结果肿瘤的位移和变形的误差在1 mm以内,胸腔的位移和变形的误差在0.5 mm以内;肿瘤在呼吸过程中沿人体竖直方向运动最大,胸腔在吸气结束时刻沿人体前后方向运动最大。结论 DVC测试技术可用于检测呼吸过程中肺部肿瘤和胸腔等胸部组织的位移和变形情况。本研究为基于DVC方法实现肺部肿瘤无创、非射线、实时的图像引导放射治疗提供了依据。
Objective To study the feasibility of digital volume correlation (DVC) method to measure the deformation and displacement of lung tumor and chest with respiratory motion. Methods DVC was used to track the three-dimensional motion in the thoracic cavity. A four-dimensional CT imaging technique was used to record a complete respiratory process in patients with lung cancer. Using the DVC software, the four characteristic lung regions were analyzed under the condition of 20%, 40%, 60%, 80% and 100% respiration phase and on the chest cavity with initial inspiratory phase as the initial state. Three-dimensional displacement values of four characteristic body regions at 100% respiratory phase. Results The errors of displacement and deformation of the tumor were within 1 mm, and the errors of the displacement and deformation of the chest cavity were within 0.5 mm. The tumor moved most vertically in the human body during respiration, and the chest moved most along the anterior and posterior direction of the human body at the end of inhalation . Conclusion The DVC test technique can be used to detect the displacement and deformation of lung tissue such as lung tumor and thoracic cavity during respiration. This study provides a basis for noninvasive, non-radiographic, real-time image-guided radiotherapy for lung cancer based on DVC.