维生素 D 缺乏性佝偻病是我国婴幼儿时期的多发病,至今仍为一世界性的问题。目前对该病的诊断仍限于临床体征、血液生化及 X 线检查。历来认为该病碱性磷酸酶(AKP)活性升高比骨 X 线改变早,而且不受季节的影响,对早期诊断具有重要参考价值。但是在临床中发现,在相当一部分佝偻病儿AKP 活力并无明显升高,甚至在激期亦无明 Vitamin D deficiency rickets is an infantile childhood disease in China, is still a worldwide problem. The current diagnosis of the disease is still limited to clinical signs, blood biochemistry and X-ray examination. It has always been thought that the activity of alkaline phosphatase (AKP) increased earlier than the bone X-ray changes, and not affected by the season, an important reference for early diagnosis. However, it was found in clinic that there was no significant increase in AKP activity in a considerable part of children with rickets,