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肝硬变(Cirrhosis of liver)是由一种或多种病因长期反复作用所致的肝的慢性、进行性、弥漫性病变.主要病理特征为肝细胞广泛变性、坏死、再生、纤维组织弥漫性增生,有肝细胞再生结节及纤维隔形成,导致正常肝小叶结构和血管结构破坏,代之以假小叶、肝变形变硬.而肝纤维化是肝硬变及慢性肝炎发展为肝硬变的主要病理过程,是肝硬变发展过程中的一个重要环节.目前临床上对肝纤维化的诊断仍以活检为主,如何寻找一种非创伤性诊断途径是国内外肝病研究颇为活跃的一项课题,近年发展迅速,本文就其实验室诊断的现状及进展作一简介.
Cirrhosis of liver is a chronic, progressive and diffuse disease of the liver caused by long-term repeated effects of one or more causes. The main pathological features are extensive degeneration, necrosis, regeneration of hepatocytes, diffuse fibrous tissue Hyperplasia, liver cell regeneration nodules and fibrous septum formation, leading to normal hepatic lobule structure and vascular structure damage, replaced by false lobules, liver degeneration and hardening of liver fibrosis is the development of cirrhosis and chronic hepatitis cirrhosis Of the main pathological process is an important part of the development of cirrhosis.Clinical diagnosis of liver fibrosis is still the main biopsy, how to find a non-invasive diagnostic approach is quite active in the study of liver disease at home and abroad A subject, developed rapidly in recent years, this article on the status of laboratory diagnosis and progress made a brief introduction.