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在整体状态下观察P物质对家兔心脏功能的影响。静脉注射3.7×10-7mol／LP物质1ml／Kg后，反映心脏功能的一些指标发生明显改变。心肌收缩成分最大缩短速率（Vmax）、左室收缩峰压（LVSP）、左室内压最大变化速率（dp／dtmax）等显著下降，左室开始收缩至发生dp／dtmax的间隔时间（t-dp／dtmax）和左室射血时间（ET）延长，左室终未舒张压（LVEDP）显著升高;心率（HR）略有减慢，而心输出量（CO）和心指数（CI）则显著升高。代表心肌耗氧的TTI及左室做功指数（LVWI）在给药后显著降低。用3.7×10-6mol／LP物质阻断剂（D—SP）1ml／kg预处理后，上述作用均可被阻断。结果表明:SP经SP受体的介导，能抑制心肌收缩性能，即对心脏有负性变力作用。
In the overall state of substance P on the rabbit heart function. Intravenous injection of 3.7 × 10-7mol / LP substance 1ml / Kg, reflect some of the indicators of cardiac function changed significantly. Vmax, LVSP and dp / dtmax of myocardial contractile components decreased significantly, and the time from left ventricular systolic to dp / dtmax (t-dp / Dtmax and prolonged left ventricular ejection time (ET), left ventricular end diastolic pressure (LVEDP) increased significantly; heart rate (HR) decreased slightly, while cardiac output (CO) and cardiac index Significantly increased. TTI and LVWI, representing myocardial oxygen consumption, were significantly reduced after administration. The above effects can be blocked by pretreatment with 1 ml / kg of 3.7 × 10 -6 mol / L substance blocker (D-SP). The results showed that: SP mediated by SP receptors, can inhibit myocardial contractility, that is, the role of the negative negative force on the heart.