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目的评价2型糖尿病患者颈总动脉内中膜厚度(intima-media thickness,IMT)、血流动力学及HbA1c水平相关性。方法选择2011年6月—2013年12月收治的初诊为2型糖尿病的患者132例,根据患者HbA1c水平分成对照组和观察组各66例,其中对照组患者的HbA1c水平低于7.0%,观察组患者的HbA1c水平高于7.0%,比较两组患者IMT、血流动力学参数阻力指数与搏动指数,并且比较两组患者的斑块发生情况。计量资料采用配对t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果观察组IMT水平、阻力指数、搏动指数分别为(1.25±0.38)mm、(0.79±0.11)、(1.62±0.33),对照组分别为(1.01±0.25)mm、(0.63±0.07)、(1.41±0.28),两组比较差异均有统计学意义(t=4.287、9.969、3.942,均P<0.05)且观察组斑块发生率为54.5%,对照组为34.8%,两组比较差异有统计学意义(χ2=5.179,P<0.05)。结论超声能够有效检测2型糖尿病患者的IMT、血流动力学水平;随着2型糖尿病患者HbA1c水平的上升,患者出现颈动脉并发症的概率上升,因此临床上需要引起重视,加强对患者HbA1c水平的监测、及早干预治疗。
Objective To evaluate the relationship between intima-media thickness (IMT), hemodynamics and HbA1c in type 2 diabetic patients. Methods A total of 132 patients with newly diagnosed type 2 diabetes admitted to our hospital from June 2011 to December 2013 were divided into control group and observation group according to the level of HbA1c in 66 patients. The HbA1c level in control group was less than 7.0% The level of HbA1c was higher than 7.0% in the two groups. IMT, hemodynamic parameters and pulsatility index were compared between the two groups, and the plaque incidence was compared between the two groups. Measurement data using paired t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results The IMT level, resistance index and pulsatility index in the observation group were (1.25 ± 0.38) mm and (0.79 ± 0.11) and (1.62 ± 0.33), respectively, and those in the control group were (1.01 ± 0.25) and (0.63 ± 0.07 and 1.41 ± 0.28). The differences between the two groups were statistically significant (t = 4.287,9.969,3.942, P <0.05). The incidence of plaque in the observation group was 54.5% and that in the control group was 34.8% Statistical significance (χ2 = 5.179, P <0.05). Conclusion Ultrasound can effectively detect IMT and hemodynamics in patients with type 2 diabetes. With the increase of HbA1c in patients with type 2 diabetes, the probability of carotid complications increases in patients with type 2 diabetes. Therefore, it is necessary to pay more attention to the clinical effect of HbA1c The level of monitoring, early intervention treatment.