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To monitor the progression of lamivudine therapy by demonstrating HBV DNAs and RNAs in the serum of achronically infected patient. Viral nucleic acids were exracted from serum samples taken during a 14-week treatmentperiod and analyzed via competitive PCR and RT/PCR. The dynamic changes in the amount as well as in the structurescan monitor therapy process very well. Our study indicated the level of polyadenylated viral RNA can be a marker forexpression in general, and the appearance of replicative intermediates as a mirror of the mode of action of an antiviraldrug.
To monitor the progression of lamivudine therapy by demonstrating HBV DNAs and RNAs in the serum of a chronically infected patient. Viral nucleic acids were exracted from serum samples taken during a 14-week treatment period and analyzed via competitive PCR and RT / PCR. The dynamic changes in the amount as well as in the structurescan monitor therapy process very well. Our study indicates the level of polyadenylated viral RNA can be a marker forexpression in general, and the appearance of replicative intermediates as a mirror of the mode of action of an antiviraldrug.