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20世纪初,Metchnikoff提出人体肠道中所寄居的细菌,尤其是大肠杆菌产生大量的毒素(吲哚、吲哚乙酸等),这些毒素能被机体吸收导致慢性中毒,从而促进衰老。这即Metchnikoff提出的衰老机理的自体中毒学说。自此即引起了广泛关注,学者们分别从不同的设想及采用不同的技术方法对肠道菌群的作用和功能进行了研究。从总体上来说均认为不论是对人类或是对动物,肠道菌群都是至关重要的。肠道菌群中尤其是小肠菌过度生长(bacterial overgrowth in the small intestine)则对机体产生诸多不利的影响。本文仅就小肠菌群过度生长作一简要综述。
At the beginning of the 20th century, Metchnikoff proposed that the bacteria colonized by the human intestine, especially E. coli, produce a large amount of toxins (indole, indole acetic acid, etc.) which can be absorbed by the body and lead to chronic poisoning, thereby promoting aging. This is Metchnikoff’s theory of autotoxicity of aging mechanisms. Since then, widespread concern has been drawn that scholars have studied the role and function of gut flora from different perspectives and using different techniques. In general, both are considered to be crucial to humans and to the animal and gut flora. Intestinal flora, especially overgrowth of the small intestine, has a number of adverse effects on the body. This article only on the overgrowth of intestinal flora make a brief review.