论文部分内容阅读
1949年Lowe和Smith报告一组病例,用DDS2～3周后出现发热、肝炎、淋巴结肿大和周围血中单核细胞异常增多,临床上酷似传染性单核细胞增多症。1951年Allday对此进行了系统描述,并命名为氨苯砜综合征(Dapsone Syndrome)以后随着DDS的广泛应用,除麻风病人外,在一些用DDS治疗的皮肤病人中亦时有发生,如寻常痤疮、掌跖脓皮病、持久性隆起性红斑、疱疹样皮炎、白细胞碎裂性血管炎等。Lowe等报告的一组麻风病人,多发生在服用DDS 100～300mg/日3～5周期间,发生率高达12％,而改用小剂量后DDS综合征的发生率明显下降,即使发生其程度也较轻。以后由于小剂量治疗而发生DDS耐药又改为大剂量,DDS综合征也随之增加。Tomeck等报告一16岁女孩
In 1949, Lowe and Smith reported a group of patients who developed fever, hepatitis, lymph nodes and peripheral mononuclear cells abnormalities in 2 to 3 weeks after DDS, clinically resembling infectious mononucleosis. In 1951, Allday systematically described this and named it Dapsone Syndrome. With the widespread use of DDS, patients with leprosy also have some cases of skin diseases in patients treated with DDS, such as Acne vulgaris, palmoplantar pustulosis, persistent erythematous erythematosus, dermatitis herpetiformis, leukocytic fibrosis and the like. Lowe reported a group of leprosy patients, occurred in taking DDS 100 ~ 300mg / day 3 to 5 weeks period, the rate as high as 12%, and switch to a small dose of DDS syndrome incidence decreased significantly, even if the extent of the occurrence Also lighter. After DDS drug resistance due to the low-dose treatment was changed to large doses, DDS syndrome also increased. Tomeck et al reported a 16-year-old girl