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震颤性麻痹(巴金森氏病)的病因、发病学和治疗问题未能彻底解决的原因之一乃是在动物身上没有复制出实验模型。临床上使用利血平治疗高血压和精神病时常出现一些与震颤性麻痹病相似的症候,所以我们用它来复制该病模型。方法与结果实验动物为50只体重200～300克的杂种大白鼠,普通喂养。药物为纯结晶利血平粉配成0.1％原液(酸化)备用。注射前用双蒸水稀释至0.01％。 15只动物一次过皮下注射利血平0.05～2毫克/
One of the reasons why etiology, epidemiology and treatment of tremor-paralysis (Parkinson’s disease) have not been completely resolved is that experimental models are not replicated in animals. Clinic use of reserpine for the treatment of hypertension and psychosis often appear some similar symptoms of tremorly paralysis, so we use it to replicate the disease model. Methods and Results The experimental animals were 50 hybrid rats weighing 200-300 g and fed on a normal diet. The drug is pure crystalline reserpine mixed into 0.1% stock solution (acidified) spare. Dilute to 0.01% with double distilled water before injection. 15 animals once subcutaneous injection of reserpine 0.05 ~ 2 mg /