论文部分内容阅读
目的:比较咪唑斯汀、氯雷他定、西替利嗪3种抗组胺药的抗组胺及抗花生四烯酸的作用。方法:给大鼠左、右爪分别皮下注射花生四烯酸(1.0g/L,0.1mL)和组胺(10g/L,0.1mL)构建鼠爪水肿炎性模型。在注射花生四烯酸和组胺2h前分别给予咪唑斯汀、氯雷他定、西替利嗪(0.6mg/kg)灌胃,注射后应用体积测量仪分别测定给药后鼠爪体积在不同时间点的变化。结果:咪唑斯汀可抑制花生四烯酸所致的鼠爪水肿(P<0.05),西替利嗪、氯雷他定对其无明显抑制作用;咪唑斯汀对组胺所致的鼠爪水肿有抑制作用(P<0.05),抑制作用强于氯雷他定组,但与西替利嗪组比较无统计学差异(P>0.05)。结论:咪唑斯汀具有抗组胺和抗花生四烯酸的作用,且其抗组胺作用强于氯雷他定;与氯雷他定、西替利嗪相比,咪唑斯汀表现出其独特的抗花生四烯酸的作用。
Objective: To compare the antihistamine and anti-arachidonic acid effects of three antihistamines, mizolastine, loratadine and cetirizine. Methods: Rat paw edema model was established by subcutaneously injecting arachidonic acid (1.0 g / L, 0.1 mL) and histamine (10 g / L, 0.1 mL) into left and right paw respectively. Before injection of arachidonic acid and histamine 2h Mizolastine, loratadine, cetirizine (0.6mg / kg) were given by intragastric administration. After injection, the volume of rat paw was measured after administration Changes at different time points. Results: Mizolastine inhibited the edema of rat paws induced by arachidonic acid (P <0.05), and cetirizine and loratadine did not significantly inhibit it. Mizolastine did not inhibit histamine induced paw edema Edema was inhibited (P <0.05), the inhibitory effect was stronger than loratadine group, but there was no significant difference compared with the cetirizine group (P> 0.05). Conclusion: Mizolastine has anti-histamine and anti-arachidonic acid effects, and its anti-histamine effect is stronger than loratadine; compared with loratadine and cetirizine, mizolastine shows its Unique anti-arachidonic acid effect.