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本文采用内、外源脾结节形成测定法和流式细胞术观察了人胎肝细胞裂解液FLL及其峰组分在γ射线照射小鼠多能造血干细胞损伤修复中的作用。证明照后24h给予FLL及峰组分4—5能明显增加受照小鼠残存造血干细胞形成CFU-S的能力,促进处于G1/0期的造血干细胞提前进入增殖状态。
In this study, the effect of FLL and its peak components of human fetal liver cell lysate on the repair of pluripotent hematopoietic stem cells in γ-ray irradiated mice was observed by the method of internal and external spleen nodule formation and flow cytometry. It was demonstrated that giving FLL and peak component 4-5 24h after irradiation significantly increased the ability of surviving hematopoietic stem cells to form CFU-S in irradiated mice and promoted the advancement of hematopoietic stem cells in G1 / 0 into proliferative state.