采用超滤浓缩技术生产人用狂犬病疫苗后 ,疫苗效力得到明显提高 ;但在使用中 ,包括过敏反应等在内的不良反应等有所增多且严重程度明显增大。以豚鼠为实验动物模型 ,探讨人用狂犬病疫苗引起过敏反应的原因。结果显示 ,地鼠肾细胞成分是引起过敏的重要物质 ,过敏的严重程度随制品浓缩倍数的增大而增大。 Vaccine efficacy has been significantly improved after the production of rabies vaccine for human using ultrafiltration concentration technology. However, adverse reactions such as allergic reactions have been increased and the severity has been significantly increased during use. Guinea pigs as experimental animal model to investigate the rabies vaccine caused by human allergic reactions. The results showed that the composition of hamster kidney cells is an important substance that causes allergies, the severity of allergies increases with product concentration multiples.