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采用钌红染色电镜观察法对正常和高脂饲食兔主动脉内膜蛋白多糖(PG)的变化进行了比较研究。结果表明正常和病变的内膜能看到两型钌红颗粒。但病变含脂区钌红颗粒数量明显减少。正常内皮细胞表面有一层钌红阳性外衣,高脂饲食20天后这层外衣开始变薄,90天几乎消失;平滑肌细胞(SMC)膜表面亦有一层钌红阳性外衣,当SMC变成泡沫细胞后,这层外衣也变薄或消失。本文讨论了内膜PG的变化与动脉粥样硬化(AS)发病学的关系。认为动脉壁PG代谢紊乱是AS发病的重要原因之一。
Ruthenium red staining was used to observe the changes of proteoglycan (PG) in the aorta of normal and high fat diet rabbits. The results show that normal and diseased intima can see two types of ruthenium red particles. However, the amount of lipid-containing ruthenium particles decreased significantly. Normal endothelial cells have a ruthenium-red-positive coat on the surface. After 20 days of high-fat feeding, the coat began to thin and disappeared almost 90 days. There was also a layer of ruthenium-red positive coat on the surface of smooth muscle cells (SMC) After this coat is also thinning or disappearing. This article discusses the relationship between changes in endometrial PG and the pathogenesis of atherosclerosis (AS). It is considered that the disturbance of PG metabolism in the arterial wall is one of the important causes of AS.