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人PBL 在体外接触抗原(37℃共育4小时)后输注给SCID 小鼠,再测试hu-PBL-SCID 小鼠对抗原的免疫应答。供体-1(血清中测不出抗HBc IgG)的PBL 移植给12只SCID 后,部分小鼠产生暂时性抗HBc IgM;对照鼠(未接触的hu-PBL-SCID)并无此抗体应答;输注含低滴度抗HBc IgG 的供体-2 PBL 后,部分小鼠出
Human PBL was inoculated to SCID mice after in vitro exposure to antigen (co-cultured for 4 hours at 37 ° C) and then tested for the immune response to the antigen in hu-PBL-SCID mice. Some mice developed transient anti-HBc IgM after 12 SCIDs were transplanted into PBL of donor-1 (undetectable anti-HBc IgG in serum); control mice (untreated hu-PBL-SCID) did not have this antibody response Some mice were sacrificed after transfusion of donor-2 PBL containing low-titer anti-HBc IgG