由于红细胞酶异常所出现的遗传性溶血性贫血的病症,是1956年发现6-磷酸葡萄糖脱氢酶(G 6PD)缺乏症和1961年发现丙酮酸激酶缺乏症之后,现已知该病由16种红细胞酶异常所引起.在世界范围内G6PD缺乏症较多,在日本以丙酮酸激酶缺乏症较多.这些病几乎都是由于结构基因变异产生了不稳定的易失活的酶,使不具有核蛋白体的成熟红细胞的能 Hereditary hemolytic anemia due to an abnormal erythrocyte enzyme disorder is found in 1956, 6-phosphoglucose dehydrogenase (G 6PD) deficiency and pyruvate kinase deficiency was found in 1961, it is known that the disease by 16 Of the abnormalities caused by erythrocytes enzymes in the world G6PD deficiency more pyruvate kinase deficiency in Japan are mostly due to structural gene mutations have produced unstable and easy to inactivate enzymes, The ability of mature erythrocytes with ribosomes