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子宫内膜异位症是一种雌激素依赖性疾病,其生物学行为源于雌激素暴露,雌激素主要通过雌激素受体发挥各种生物效应。激活蛋白1是一种重要的核转录调控因子,参与细胞增殖、分化和凋亡等多种生理过程。现综述雌激素受体不同亚型及激活蛋白1结构、功能及其在在位内膜、异位内膜中的表达,探讨其在子宫内膜异位症发生、发展中的作用。
Endometriosis is an estrogen-dependent disease whose biological behavior is due to estrogen exposure. Estrogens exert various biological effects mainly through estrogen receptors. Activator protein 1 is an important nuclear transcription regulator, which is involved in many physiological processes such as cell proliferation, differentiation and apoptosis. We reviewed the different subtypes of estrogen receptor and the activation of protein 1 structure, function and eutopic endometrium, ectopic endometrial expression, to explore its role in the occurrence and development of endometriosis.