自1910～1913年间,Legendre和Pieron报告了在剥夺睡眠狗的血液、脑和脑脊液中可能存在某种具有催眠作用的物质后,许多工作者相继对这种物质进行了大量的研究,这些工作从不同的动物、不同的组织中成功地得到了多种具有催眠作用的活性物质。 Monnier及共同工刺激家兔丘脑的睡眠区使其入睡,然后对它们的血液进行透析,得到了一个分子量 Since 1910-1913, when Legendre and Pieron reported that there may be some hypnotic substance in the blood, brain and cerebrospinal fluid of sleep deprived dogs, many workers have conducted extensive studies on this material one after another Different animals, different organizations have been successfully obtained a variety of hypnotic activity of the active substance. Monnier and co-workers stimulated the sleep regions in the thalamus of rabbits to fall asleep and then dialyzed their blood for a molecular weight