论文部分内容阅读
微量元素铜和锌不仅具有十分重要的生理功能,而且与许多疾病的发生、发展密切有关。我们曾报告实验性矽肺、煤矽肺大白鼠血清铜明显升高,而且这种变化与病程长短,病变程度及粉尘性质不同有相关性。血清铜大部分与铜蓝蛋白结合,参与胶原纤维的供价交联,因而在尘肺患者出现铜蓝蛋白增高。据此,临床上试用检查血浆铜蓝蛋白的方法判断矽肺的期别,评价药物的疗效。但铜除参与铜蓝蛋白合成外,也是血清中赖氨酸氧化酶、过氧化物歧化酶等的重要成分,而且人体中铜蓝蛋白尚无统一的正常值,测定的结果各家不一。本文采用原子吸收光谱法测定血清中总铜和锌,旨在探讨各期煤工尘肺患者血清铜、锌变化的规律及其临床意义。
Trace elements copper and zinc not only have very important physiological functions, but also with the occurrence and development of many diseases. We have reported experimental silicosis, coal silicosis rats significantly increased serum copper, and this change and duration of the disease, the degree of lesion and the different nature of the dust have a correlation. Most serum copper and ceruloplasmin binding, involved in collagen fibers for the price of cross-linked, so patients with pneumoconiosis ceruloplasmin increased. Accordingly, the clinical trial to check the method of ceruloplasmin to determine the stage of silicosis, evaluate the efficacy of drugs. However, copper is not only involved in the synthesis of ceruloplasmin, but also an important component of serum lysine oxidase and superoxide dismutase. Moreover, there is no uniform normal value of ceruloplasmin in the human body, and the results of the determination vary from one family to another. In this paper, total copper and zinc in serum were determined by atomic absorption spectrometry, and the aim was to investigate the changes of serum copper and zinc in coal workers with pneumoconiosis and their clinical significance.