血吸虫性肝纤维化形成过程包括肝损害、细胞因子改变和细胞外间质代谢异常3个阶段。在虫卵肉芽肿的持续作用下造成慢性肝损害，激活了胶原纤维生成细胞，产生大量胶原纤维，导致干线型肝纤维化。巨脾型晚期血吸虫病患者肝胶原分布部位与正常人相似：Ⅰ、Ⅲ型胶原主要分布于肝汇 Schistosome-induced liver fibrosis includes liver damage, changes in cytokines and extracellular metabolism of extracellular matrix in three stages. The continued role of the egg granuloma caused by chronic liver damage, activated collagen fibers to produce cells, resulting in a large number of collagen fibers, leading to trunk-type liver fibrosis. Patients with splenic type of advanced schistosomiasis hepatic collagen distribution and normal people similar: Ⅰ, Ⅲ type collagen is mainly distributed in the liver