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氢质子磁共振波谱（1 HMRS）是近年来发展迅速的无创检测活体组织内化学代谢物质的技术手段，对物质改变敏感且可重复性高。1 HMRS作为一种客观的特异性指标已成为痴呆的主要研究手段，有效弥补了其诊断主要依赖于临床表现和认知量表的状况。1 HMRS 已被证实在痴呆的早期诊断、鉴别诊断、治疗监测等方面具有重要的作用。因此，痴呆最主要的类型阿尔茨海默病是1 HMRS的研究热点。“,”Proton magnetic resonance spectroscopy(1HMRS) is a noninvasive test technology for living tissue chemical metabolite changes with rapid development in recent years ,which is sensitive and repeatable. As an objective specific indicator,1 HMRS has been the major research approach for dementia,which is an effective supplement for the situation that the diagnosis of dementia is mainly dependent on the clinical mani-festation and scale analysis.1HMRS has been confirmed to play an important role in the early diagnosis,dif-ferential diagnosis and treatment monitoring of dementia.Therefore,Alzheimer disease,which is the major subtype of dementia,is the research focus of 1 HMRS.