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目的分析慢性支气管炎急性加重期病原菌的类型、分布以及药物敏感性试验的情况。方法收集2004年1月至2007年12月我所住院的慢性支气管炎急性加重期患者共送检168例次痰标本进行培养和药物敏感试验。结果从痰液中共检出156株需氧菌,其中革兰阴性菌93株(59.62%),革兰阳性菌41株(26.28%),真菌22株(14.1%);在革兰阴性菌中,以克雷伯菌属为主,占总分离率的21.15%(33/156),其次是铜绿假单胞菌,分离出24株(15.38%);革兰阳性菌则以金黄色葡萄球菌及肺炎链球菌居多。感染以革兰阴性杆菌为主,对11种临床常用的抗生素敏感率较高的是亚胺培南,其次是氨基糖苷类。结论本试验可提高对慢性支气管炎的临床诊断,根据其病原学特点合理使用抗菌药物。
Objective To analyze the types, distribution and drug sensitivity test of pathogens in acute exacerbation of chronic bronchitis. Methods A total of 168 sputum samples were collected from patients with acute exacerbation of chronic bronchitis admitted to our hospital from January 2004 to December 2007 for culture and drug susceptibility testing. Results A total of 156 strains of aerobic bacteria were detected in sputum, among which, 93 (59.62%) were gram-negative bacteria, 41 (26.28%) were gram-positive bacteria and 22 (14.1%) were fungi. , Which accounted for 21.15% (33/156) of the total isolates, followed by Pseudomonas aeruginosa and 24 isolates (15.38%). Klebsiella spp. Belonged to Staphylococcus aureus And Streptococcus pneumoniae mostly. Infected with gram-negative bacilli, the 11 kinds of antibiotics commonly used clinically sensitive high imipenem, followed by aminoglycosides. Conclusion This test can improve the clinical diagnosis of chronic bronchitis, rational use of antimicrobial agents according to their etiological characteristics.