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目的 探讨肺结核患者结核分枝杆菌L型的检测及其临床意义。方法 对 12 4例活动性肺结核和 2 2例非活动性肺结核患者 ,分别作痰抗酸染色涂片、改良罗氏培养、BACTEC 960培养和结核分枝杆菌L型培养。结果 痰结核分枝杆菌L型培养阳性率显著高于改良罗氏培养 ,差异有显著性 (χ2 =4.6873 ,P <0 .0 5 ) ,也高于抗酸染色涂片和BACTEC 960培养 ,但差异无显著性 (P >0 .0 5 )。活动性肺结核患者L型培养阳性率为60 .48% ,显著高于非活动性肺结核患者 (χ2 =19.85 65 ,P <0 .0 0 1)。病程越长 ,痰结核分枝杆菌L型阳性率越高 ,但仅病程 >1年者与 <1个月者之间差异有显著性 (P <0 .0 5 )。复治病例L型培养阳性率显著高于初治病例 (χ2 =4.0 5 78,P <0 .0 5 )。有空洞患者L型培养阳性率为 71.19% ,显著高于无空洞患者 (χ2 =5 .3 941,P <0 .0 5 )。耐药和耐多药患者L型培养阳性率均显著高于敏感患者 (P <0 .0 5 )。化疗开始时痰结核分枝杆菌L型阳性者 ,化疗 6个月末痰菌阴转率显著低于L型阴性者 (χ2 =3 .913 8,P <0 .0 5 )。结论 结核分枝杆菌L型培养可提高结核分枝杆菌的阳性检出率 ,对结核病的早期、快速诊断具有重要价值。结核分枝杆菌L型感染X线表现特点为干酪样病变和空洞多。结核分枝杆菌L型耐药率高 ,临?
Objective To investigate the detection of Mycobacterium tuberculosis L-type in patients with pulmonary tuberculosis and its clinical significance. Methods Totally 12 4 patients with active pulmonary tuberculosis and 22 patients with inactive pulmonary tuberculosis were treated with sputum acid-fast staining, modified Roche culture, BACTEC 960 culture and Mycobacterium tuberculosis L-type culture. Results The positive rate of L-form of Mycobacterium tuberculosis was significantly higher than that of modified Roche culture (χ2 = 4.6873, P <0.05), but also higher than that of acid-fast staining and BACTEC 960 No significant (P> 0.05). The positive rate of L-type culture in patients with active pulmonary tuberculosis was 60.48%, significantly higher than those in inactive pulmonary tuberculosis (χ2 = 19.8565, P <0.01). The longer the course of disease, the higher the positive rate of L-type sputum Mycobacterium tuberculosis, but only the duration of> 1 year and <1 month difference was significant (P <0. The positive rate of L-type culture in retreatment cases was significantly higher than that of the newly diagnosed cases (χ2 = 4.0578, P <0.05). The positive rate of L-type culture in patients with empty cavity was 71.19%, which was significantly higher than those without cavity (χ2 = 5.939, P <0.05). The positive rate of L-type culture in resistant and multi-drug resistant patients was significantly higher than that in sensitive patients (P <0.05). At the beginning of chemotherapy, patients with positive sputum of Mycobacterium tuberculosis L had a significantly lower sputum negative conversion rate at the end of 6 months of chemotherapy than those with negative L type (χ2 = 3.913 8, P <0.05). Conclusion Mycobacterium tuberculosis L-type culture can increase the positive detection rate of Mycobacterium tuberculosis, which is of great value in early diagnosis and rapid diagnosis of tuberculosis. Mycobacterium tuberculosis L-type infection X-ray findings for the case-like lesions and holes and more. Mycobacterium tuberculosis L-resistant rate is high, Pro?