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目的观察清痹饮合小剂量甲氨喋呤治疗类风湿关节炎(RA)发作期的临床疗效。方法将55例急性发作期RA患者随机分为2组。对照组口服甲氨喋呤片(MTX)治疗;治疗组口服小剂量甲氨喋呤片并给予清痹饮口服;2月后观察临床疗效及不良发应。结果总有效率治疗组86.7%,对照组64.0%,2组总有效率比较,有差异有显著性(P<0.05),治疗组优于对照组;治疗后两组患者的关节痛、肿胀、功能、晨僵等症状体征积分均有不同程度的改变(P<0.05),改变程度上治疗组明显优于对照组(P<0.01),同时血沉(ESR)、类风湿因子(RF)、C反应蛋白(CRP)等实验室指标均有明显下降,治疗组明显优于对照组(P<0.05);治疗组药物不良反应明显少于对照组。结论清痹饮联合小剂量甲氨喋呤,能有效缓解类风湿关节炎发作期症状,且不良反应小,值得临床推广使用。
Objective To observe the clinical effect of Qingbi Decoction combined with low-dose methotrexate on the onset of rheumatoid arthritis (RA). Methods 55 patients with acute exacerbation of RA were randomly divided into two groups. The control group was given methotrexate tablets (MTX) orally. The treatment group was orally administered with small doses of methotrexate tablets and oral qingbi. After 2 months, the curative effect and adverse reactions were observed. Results The total effective rate was 86.7% in the treatment group and 64.0% in the control group. The total effective rate in the two groups was significantly different (P <0.05), and the treatment group was better than the control group. The joint pain, swelling, (P <0.05). The degree of change in the treatment group was significantly better than that in the control group (P <0.01), ESR, RF, C CRP and other laboratory indicators were significantly decreased, the treatment group was significantly better than the control group (P <0.05); adverse reactions in the treatment group was significantly less than the control group. Conclusion Qingbi Decoction combined with low-dose methotrexate can effectively relieve the symptoms of rheumatoid arthritis attack, and the adverse reaction is small, worthy of clinical promotion and use.