窒息是早产儿的常见疾病,可用甲基黄嘌呤类药物治疗。本文研究了吗乙苯吡酮对耐氨茶硷治疗的严重特发性窒息患儿的效力和安全性。方法:研究了11名耐氨茶硷治疗的特发性窒息患儿,平均妊娠29.9±1.8周(范围28～30周),平均出生时体重1,120±200g(范围780～1,400g,当实验室检查结果均正常并排除了其它可能的)外界因素时,即确诊为特发性窒息。每8小时伴3次以上的严重窒息发作的患儿开始以氨茶硷6mg/kg静注,继之以1.5mg/kg,每8小时1次。每天检测2次血药浓度。当治疗效果不佳时即停药,代之以吗乙苯吡酮2.5mg/kg/小时持续静滴。若窒息发作得以控制,连用4天;若未奏效,12小时 Asphyxia is a common disease in preterm infants and can be treated with methylxanthines. This article studies the efficacy and safety of eprinometrine in children with severe idiopathic asphyxia treated with aminophylline. METHODS: Eleven patients with idiopathic asphyxia treated with aminophylline were studied, with an average of 29.9 ± 1.8 weeks (range, 28-30 weeks) and an average birth weight of 1,120 ± 200 g (range, 780-1,400 g) The test results were normal and ruled out other possible) external factors, that is diagnosed as idiopathic asphyxia. Children with severe asphyxia episodes of more than 3 episodes every 8 hours started intravenous aminophylline 6 mg / kg followed by 1.5 mg / kg every 8 hours. Test blood concentration twice a day. When the treatment is not good when the withdrawal, instead of ethyl benzopyrone 2.5mg / kg / hour continuous intravenous infusion. If suffocation episodes can be controlled, once every 4 days; if did not work, 12 hours