我国自主研发的抗HIV药物已经进入早期临床实验阶段.该类药物早期临床实验在遵循药物临床实验的一般规律外,尚具有其特殊性.结合国内外文献资料及审评积累,介绍了对抗HIV药物人体耐受性、人体药代动力学、剂量探索性等研究中特性问题的思考与认识. Our country independently developed anti-HIV drugs have entered the early clinical trial phase of the early clinical trials of these drugs in addition to follow the general laws of drug clinical trials, but also has its own particularity.Combined with domestic and foreign literature and review accumulation, describes the fight against HIV Drug tolerance, human pharmacokinetics, dose exploration and other characteristics of the study of thinking and understanding.