肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑,抑 Pulmonary arterial hypertension (PAH) is a serious progressive disease, one of the signs of pulmonary vascular remodeling. Nicotinamide phosphoribosyl transferase (nicotinamide phosphoribosyl transferase, nicotinamide phosphoribosyltransferase (nicotinamide phosphoribosyltransferase, is a regulator of intracellular nicotinamide adenine dinucleotide levels, redox state, regulate histone deacetylase, promote cell proliferation and inhibition of apoptosis Cell enzyme. The researchers hypothesized that NAMPT promotes pulmonary vascular remodeling