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分析了４６例肝炎后肝硬化失代偿期病人骨密度改变的临床特点及其与血钙、血磷、血清碱性磷酸酶（ＡＫＰ）和维生素Ｄ代谢的关系，其结果表明：①肝硬化病人骨矿物质含量（ＢＭＣ）较正常对照组减低（Ｐ＜０．０５），尤以年龄＞５０岁者减低更显著（Ｐ＜０．０１）；②肝硬化组血钙、磷减低，而ＡＫＰ升高（Ｐ＜０．０１）；③ＢＭＣ减低时，其血清钙、磷亦减低（Ｐ＜０．０１），且随着肝硬化病情的进展，此种改变越加明显。其原因系：①肝硬化时，使维生素口代谢障碍；②肠道钙吸收减少；③营养失调。故我们认为肝硬化致骨质疏松症的发生是由多种因素综合作用的结果。
The clinical features of bone mineral density changes in 46 patients with decompensated liver cirrhosis and their relationship with serum calcium, serum phosphorus, serum alkaline phosphatase (AKP) and vitamin D metabolism were analyzed. The results showed that: ① cirrhosis Bone mineral density (BMC) in patients with liver cirrhosis was significantly lower than that in controls (P <0.05), especially in those aged> 50 years (P <0.01) AKP increased (P <0.01). ③The serum calcium and phosphorus decreased when BMC decreased (P <0.01), and this change became more obvious with the progression of cirrhosis. The reason is: ① liver cirrhosis, vitamin metabolism disorders; ② reduce intestinal intestinal absorption; ③ malnutrition. Therefore, we believe that the occurrence of cirrhosis caused by osteoporosis is the result of a combination of many factors.