论文部分内容阅读
目的:观察二甲双胍与复方醋酸环丙孕酮对多囊卵巢综合征(PCOS)患者内分泌、糖及脂代谢的影响,了解二甲双胍预防心血管疾病的作用。方法:将50名PCOS患者随机分为两组,分别用二甲双胍或复方醋酸环丙孕酮共3个周期。用药前后观察体重指数(BMI)、腰臀比(WHR),并检测血脂、胰岛素、血糖胰岛素比值(Glucose-to-Insulin ratio,GIR)和性激素。结果:用二甲双胍治疗后BMI、WHR、血脂、胰岛素水平下降,GIR上升;复方醋酸环丙孕酮可使血睾酮明显下降,对血脂、胰岛素和GIR无影响。结论:二甲双胍治疗PCOS可减轻体重、改善血脂、提高胰岛素敏感性,有利于预防心血管疾病。
Objective: To observe the effects of metformin and cyproterone acetate on endocrine, glucose and lipid metabolism in patients with polycystic ovary syndrome (PCOS) and to understand the role of metformin in the prevention of cardiovascular diseases. Methods: Fifty patients with PCOS were randomly divided into two groups, with metformin or compound cyproterone acetate for a total of three cycles. Body mass index (BMI) and waist - to - hip ratio (WHR) were observed before and after treatment. Lipids, insulin, Glucose - to - Insulin ratio (GIR) and sex hormones were measured. Results: After treatment with metformin, BMI, WHR, blood lipids, insulin levels decreased, GIR increased; compound cyproterone acetate significantly decreased blood testosterone, blood lipids, insulin and GIR no effect. Conclusion: Metformin treatment of PCOS can reduce body weight, improve blood lipids, improve insulin sensitivity, is conducive to the prevention of cardiovascular disease.