所有抗代谢药有两个特点—抑制DNA(去氧核醣核酸)的合成,以及对全身的毒性作用。核分裂指数高的组织最易受损,也对它最敏感。牛皮癣有大量的表皮增生,这种增生也发现在临床上未受侵犯的皮肤上。受侵皮肤DNA合成增快,胸腺核苷结合增加。也发现牛皮癣病人蛋白质代谢不正常,表皮出现不正常 All antimetabolites have two characteristics - inhibition of DNA (DNA) synthesis, and systemic toxicity. Organizations with high mitotic index are the most vulnerable and most sensitive to it. Psoriasis has a large number of epidermal hyperplasia, this proliferation is also found in clinically non-invasive skin. Infected skin DNA synthesis increased, thymosin binding increased. Also found that patients with psoriasis protein metabolism is not normal, the epidermis appears abnormal