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本文对７１例形态学（Ｍｏｒｐｈｏｌｏｇｙ）诊断为急性早幼粒细胞白血病（ＡＰＬ）的初发患者骨髓标本同时进行了免疫学（Ｉｍｍｕｎｏｌｏｇｙ）、细胞遗传学（Ｃｙｔｏｇｅｎｅｔｉｃｓ）和分子生物学（Ｍｏｌｅｃｕｌａｒｂｉｏｌｏｇｙ）（简称ＭＩＣＭ）的分型研究。典型的ＡＰＬ免疫学粒细胞抗体中ＣＤ３３、ＣＤ１３有很高的表达；染色体核型为ｔ（１５；１７）（ｑ２２；ｑ１１～２１）；ＲＴ／ＰＣＲ检测可见ＰＭＬ／ＲＡＲα融合基因。这种ＡＰＬ占本组病例的９５．８％。另二例有其他的染色体易位和基因的异常。提示ＡＰＬ是不均一性疾病。
In this paper, 71 patients with morphology (Morphology) diagnosed as acute promyelocytic leukemia (APL) were treated with immunology, cytogenetics, and molecular biology (abbreviation). Typing study of MICM). Typical APL immunological granulocyte antibodies have high expression of CD33 and CD13; karyotypes are t(15;17)(q22;q11~21); PML/RARα fusion gene can be detected by RT/PCR. This APL accounts for 95.8% of this group of cases. The other two cases had other chromosomal translocations and gene abnormalities. It is suggested that APL is an inhomogeneous disease.