目的：研究双酚胺酸（ＣＢＭＩＤＡ）对氯化镍的解毒作用．方法：ＮｉＣｌ２中毒后，立即给予ＣＢＭＩＤＡ，记录动物存活数；小鼠ｉｖ６３ＮｉＣｌ２后给药，测定２４ｈ组织中６３镍；用整体放射自显影术，显示小鼠体内６３镍分布．结果：ｓｃＣＢＭＩＤＡ０５－１５ｇ·ｋｇ－１对ｉｐＮｉＣｌ２５００ｍｇ·ｋｇ－１有解毒作用；小鼠ｉｐＮｉＣｌ２ＬＤ５０为８２８ｍｇ·ｋｇ－１，给药１５或２５ｇ·ｋｇ－１，ＬＤ５０分别为７８９和８２０ｍｇ·ｋｇ－１；大鼠ｉｍＣＢＭＩＤＡ５００ｍｇ·ｋｇ－１使ＮｉＣｌ２的ＬＤ５０提高８倍；组织中６３镍测定和定位显示，ＣＢＭＩＤＡ减少肺和血液中６３镍，增加了骨中６３镍，２４ｈ尿、粪６３镍排出与对照组无明显差异．结论：ＣＢＭＩＤＡ有效地解除镍毒性，提高动物存活率，降低镍在肺部的滞留． Objective: To study the detoxification effect of CBMIDA on nickel chloride. Methods: Immediately after the NiCl2 poisoning, CBMIDA was given and the number of animals survived. The mice were treated with iv63NiCl2, and 63 nickel in 24h tissue was measured. The whole body of 63 Ni was detected by whole autoradiography. Results: The scCBMIDA0.5-15g · kg-1 had antidote to ipNiCl2500mg · kg-1, the ipNiCl2LD50 was 828mg · kg-1 and the dose of 15 or 25g · kg-1, LD50 Respectively, 789 and 820 mg · kg-1; the imCBMIDA 500mg · kg-1 increased the LD50 of NiCl2 by 8 times. The determination and localization of 63 Ni in the tissues showed that CBMIDA decreased 63 Ni in the lung and blood, increased 63 Ni in the bone, 24h urinary excretion of 63 nickel and no significant difference between the control group. CONCLUSION: CBMIDA effectively relieves nickel toxicity, improves animal survival and reduces nickel retention in the lung.