随着医药科学技术的发展,临床医师和药剂工作者已普遍注意到大输液中存在较多微粒会对人体带来严重危害。英、美等国早已将大输液中的微粒限度列入国家药典。我国药剂工作者对输液制备工艺中如何控制微粒也提出了很多有效措施~([1、2])。但是,在临床应用中,输液与其它药物配伍后出现的微粒变化尚未引起足够重视,国内也尚少报 With the development of medical science and technology, clinicians and pharmacy workers have generally noticed that the presence of more particles in large transfusion fluids can cause serious harm to the human body. Britain, the United States and other countries have already included in the infusion of particles limit the national pharmacopoeia. Pharmacists in our country also put forward many effective measures on how to control the particles in the infusion preparation process ([1,2]). However, in clinical application, the change of the particles after the combination of infusion and other drugs has not been given sufficient attention, and there are still few reports in China