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应用免疫组织化学技术对１６１例进展期胃癌行嗜铬粒蛋白Ａ（ＣｇＡ）抗体染色。将检出有ＣｇＡ阳性癌细胞的胃癌７３例，癌旁粘膜６３例行蛙皮素（Ｂｏｍｂｅｓｉｎ，ＢＯＭ）及胃泌素（Ｇａｓｔｒｉｎ，ＧＡＳＴ）抗体染色。应用图像分析系统对癌旁粘膜内分泌细胞进行定量测量。结果显示７３例ＣｇＡ阳性胃癌中１５例ＢＯＭ呈阳性表达，ＢＯＭ阳性胃癌均为低分化胃癌。癌旁胃窦粘膜无萎缩组，ＢＯＭ阳性细胞平均计数较正常对照组明显增多（Ｐ＜００１），且多为弥漫型癌（８５％）。蛙皮素在胃癌及癌旁粘膜中的表达与胃泌素相似。提示蛙皮素有刺激胃癌生长的作用，其作用可能部分是通过刺激胃泌素的释放，部分是直接作用于肿瘤细胞。
Immunohistochemical technique was used to stain chromogranin A (CgA) antibody in 161 patients with advanced gastric cancer. Seventy-three cases of gastric cancer with CgA positive cancer cells were detected, and 63 cases of paracancerous mucosa were stained with antibodies against Bombesin (BOM) and Gastrin (GAST). The image analysis system was used to quantitatively measure the paracancerous mucosal endocrine cells. The results showed that the expression of BOM was positive in 15 cases of 73 cases of CgA-positive gastric cancer, and the positive cells of BOM were poorly differentiated gastric carcinoma. There was no atrophy group in the paragastric antral mucosa. The average count of BOM-positive cells was significantly higher than that in the normal control group (P<001), and most of them were diffuse type carcinoma (85%). Bombesin is similar to gastrin in gastric cancer and paraneoplastic mucosa. It is suggested that the role of bombesin in stimulating the growth of gastric cancer may be partly by stimulating the release of gastrin, and partly by directly acting on the tumor cells.