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本文采用ＲＰ－ＨＰＬＣ法检测国内外重组人生长激素经胰蛋白酶裂解的肽片段，并与天然人生长激素对比，肽图谱分析的结果表明，重组人生长激素与其天然产物的分子结构具有同一性，国内各批产品的蛋白质一级结构具有一致性。ＨＰＬＣ胰肽图谱分析为基因工程多肽药物的质量控制提供了一种有效手段。
In this paper, RP-HPLC assay of recombinant human growth hormone tryptic cleavage of peptide fragments and compared with natural human growth hormone peptide mapping analysis showed that the recombinant human growth hormone and its natural product molecular structure of identity, Domestic batches of products of the protein structure is consistent. HPLC isopeptide peptide mapping provides an effective tool for the quality control of genetically engineered peptide drugs.