胰岛素受体、胰岛素抗体和胰岛素抗性是三个不同的概念,它们与胰岛素的作用原理、变态反应和耐受现象密切相关,弄清它们的本质、特性与内在联系,对糖尿病治疗有重要临床意义。一、胰岛素受体胰岛素的作用原理虽从多方面作了深入研究,但其精确机制仍不详尽。Cuatrecasas(1972)首先用表面活化剂三硝基甲苯(triton X-100)处理细胞膜,分 Insulin receptors, insulin antibodies and insulin resistance are three different concepts, which are closely related to insulin action principle, allergy and tolerance phenomenon, clarify their essence, characteristics and internal relations, and have important clinical significance in the treatment of diabetes significance. First, the insulin receptor Insulin action principle Although made in-depth study from many aspects, but the precise mechanism is still not exhaustive. Cuatrecasas (1972) first treated cell membrane with surfactant triton X-100