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目的分析急性冠状动脉综合征患者全血CD40L和CD64检测结果。方法分别应用流式细胞术技术对30例AMI组,30例UAP组及20例健康对照组的全血CD40L和CD64及其T淋巴细胞亚群检测。结果 CD40L,CD64在AMI组,UAP组与健康对照组比较中明显高于健康对照组,而T淋巴细胞亚群变化不显著。AMI组CD40L,CD64明显高于UAP组,而UAP组明显高于健康对照组,差异有统计学意义(P<0.05)。结论全血CD40L和CD64量的升高可能与急性冠状动脉综合征的发生有关,可能是动脉粥样硬化斑块不稳定的敏感标志。
Objective To analyze the results of whole blood CD40L and CD64 in patients with acute coronary syndrome. Methods The whole blood CD40L, CD64 and T lymphocyte subsets of 30 patients with AMI, 30 patients with UAP and 20 healthy controls were detected by flow cytometry. Results CD40L and CD64 in AMI group and UAP group were significantly higher than those in healthy control group, but T lymphocyte subsets did not change significantly. The levels of CD40L and CD64 in AMI group were significantly higher than those in UAP group, while those in UAP group were significantly higher than those in healthy control group (P <0.05). Conclusion The increase of CD40L and CD64 in whole blood may be related to the occurrence of acute coronary syndrome and may be a sensitive marker of atherosclerotic plaque instability.