有关母血清甲胎球蛋白(AFP)与神经管缺陷的报告已见于1977年.筛选母血清AFP浓度可鉴定79%开放性脊柱裂婴儿的妊娠,未经筛选者约15%为死产.假如决定施行手术流产,更能体现筛选的价值.幸存婴儿的40%可生存至五年以上,但绝大部分有严重的功能缺陷.本研究旨在确定幸存的开放性脊柱裂婴儿与母血清AFP浓度的关系.本研究采用间接途径调查了97例在孕10-24周测得的母血清AFP浓度、婴儿生存时限和其功 A report on maternal serum alpha-fetoprotein (AFP) and neural tube defects was reported in 1977. Screening for AFP concentrations in maternal serum identified 79% of open-spina bifida babies who were stillborn at about 15% of unselected pregnancies Decided to implement the surgical abortion, better reflect the value of screening.40% of surviving babies can survive to more than five years, but most have serious functional deficiencies.This study aimed to determine the survival of open spina bifida and maternal serum AFP Concentration.This study investigated the 97 cases of serum concentrations of AFP measured at 10-24 weeks of pregnancy, the survival time of infants and their merit by indirect method