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2例女性患者(例1为67岁,例2为34岁)因皮疹分别服用氯雷他定10 mg,1次/d。于服药第67、天分别出现皮肤、巩膜黄染,并伴有尿色加深、食欲不振。实验室检查:例1总胆红素(TBil)204.3μmol/L,直接胆红素(DBil)108.24μmol/L,间接胆红素(IBil)96.06μmol/L,丙氨酸转氨酶(ALT)917 U/L,天冬氨酸转氨酶(AST)904 U/L;例2 TBil 85.3μmol/L,DBil 44.80μmol/LI,Bil 40.50μmol/L,ALT1565 U/L。均给予保肝、退黄治疗,症状逐渐好转,肝功能分别于治疗后40和14 d恢复正常。
Two female patients (67 in case 1 and 34 in case 2) received loratadine 10 mg once daily for the rash. In the first 67 days of medication, respectively, the skin, scleral yellow dye, and accompanied by dark urine, loss of appetite. Laboratory tests: Example 1 204.3 μmol / L TBil, 108.24 μmol / L DBil, 96.06 μmol / L IBT, 917 ALT, U / L, aspartate aminotransferase (AST) 904 U / L; Example 2 TBil 85.3 μmol / L, DBil 44.80 μmol / LI, Bil 40.50 μmol / L, ALT 1565 U / L. All were given liver protection, Huang treatment, symptoms gradually improved, liver function were returned to normal 40 and 14 d after treatment.