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目的:探讨肿瘤科护士工作压力、心理一致感与共情疲劳三者的关系，研究心理一致感在肿瘤科护士工作压力与共情疲劳间的中介作用。方法:采用便利抽样法，选取2019年11月—2020年1月安徽省7所三级甲等医院的370名肿瘤科护士为研究对象，采用中国护士工作压力源量表、心理一致感量表、护士专业生活品质量表及一般资料调查表进行调查，采用AMOS 21.0和SPSS 23.0软件对数据进行统计分析。发放问卷370份，回收有效问卷345份。结果:肿瘤科护士工作压力与心理一致感呈负相关（n r=-0.547，n P<0.01），与工作倦怠、二次创伤呈正相关（n r值分别为0.607、0.418；n P<0.01）；心理一致感与工作倦怠、二次创伤呈负相关（n r值分别为-0.581、-0.405；n P<0.01）。心理一致感在肿瘤科护士工作压力与工作倦怠、二次创伤间起部分中介作用，中介效应分别占总效应的45.81%、33.82%。n 结论:心理一致感是肿瘤科护士工作压力与共情疲劳间的中介变量，积极评估护士的心理一致感水平并予以干预，有利于降低因工作压力导致的共情疲劳水平。“,”Objective:To explore the relationship between work stress, sense of coherence (SOC) and compassion fatigue (CF) among oncological nurses, and to study the mediating role of SOC between work stress and CF in oncological nurses.Methods:Totally 370 oncological nurses from 7 ClassⅢ Grade A hospitals in Anhui Province between November 2019 and January 2020 were conveniently selected and investigated with the Chinese Nurse Work Stressor Scale, Sense of Coherence Scale-13, Professional Quality of Life and the general information questionnaire. AMOS 21.0 and SPSS 23.0 were used for statistical analysis of the data. A total of 370 questionnaires were distributed and 345 valid questionnaires were returned.Results:The work stress of oncological nurses was negatively correlated with their SOC (n r=-0.547, n P<0.01) , and positively correlated with job burnout and secondary trauma (n r=0.607, 0.418; n P<0.01) ; SOC was negatively correlated with job burnout and secondary trauma (n r=-0.581, -0.405; n P<0.01) . SOC played a mediating role between the work stress, job burnout and secondary trauma of oncological nurses, and the mediating effect accounted for 45.81% and 33.82% of the total effect, respectively.n Conclusions:SOC is a mediating variable between the work stress and CF of oncological nurses. Actively assessing the level of nurses' SOC and providing interventions are helpful to reduce CF caused by work stress.