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本实验旨在研究苯妥英钠（ＰＳ）对伤口巨噬细胞（Ｍ）的影响．从置入大鼠背部伤口的聚乙烯醇海绵中收集巨噬细胞，分别测定其吞噬功能，肿瘤坏死因子α（ＴＮＦα）和白介素１（ＩＬ－１）的释放以及对成纤维细胞增殖调节作用，通过牵拉伤口组织致其断裂时溢出的水的重量而测定伤口牵张强度．结果表明，伤口Ｍ的功能在伤后ｄ５达到高峰，ＰＳ１，１０，５０ｇ·Ｌ－１浓度依赖性地增加伤后ｄ５的伤口Ｍ的数量，吞噬功能，ＴＮＦα和ＩＬ－１的释放，增强Ｍ对成纤维细胞增殖的刺激作用，增强伤口牵张强度．结果说明ＰＳ加速伤口愈合，与其增强Ｍ的功能有关．
This experiment aimed to investigate the effect of phenytoin sodium on wound macrophages (M). Macrophages were collected from polyvinyl alcohol sponges implanted into the back of rats, and phagocytosis, release of tumor necrosis factor α (TNFα) and interleukin-1 (IL-1), and regulation of fibroblast proliferation were measured respectively. The wound stretch strength was determined by pulling the wound tissue through the weight of water that spilled on breaking. The results showed that the function of wound M 达 reached its peak at day 5 after injury. PS1,10,50 g · L-1 dose-dependently increased the number of M, the phagocytic function, the release of TNFα and IL-1, Enhance the stimulating effect of M on the proliferation of fibroblasts and enhance the wound stretch strength. The results suggest that PS accelerates wound healing in relation to its ability to enhance M.