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观察糖尿病患者血栓前状态若干相关分子标志物即血浆内皮素－ １（ＥＴ－ １） 、血小板α－ 颗粒膜蛋白（ＧＭＰ－１４０）、组织纤溶酶原激活物（ｔＰＡ） 及其抑制物（ＰＡＩ－ １） 的变化。方法：分别采用放免法和发色底物显色法，检测了２０ 例正常人和４０ 例Ⅱ型糖尿病患者（２２ 例无微血管病变，１８ 例有微血管病变）的ＥＴ－１ 、ＧＭＰ－１４０ 、ｔＰＡ及ＰＡＩ－ １ 的变化。结果：糖尿病患者的ＥＴ－ １、ＧＭＰ－ １４０ 、ＰＡＩ－ １ 显著高于正常对照组，ｔＰＡ 则明显下降，伴微血管病变者比无微血管病变者变化更明显，且ＥＴ－ １ 与ＧＭＰ－ １４０ 、ＰＡＩ－ １ 呈显著正相关，而与ｔＰＡ 呈显著负相关。结论：上述血栓前状态若干相关分子标志物的测定对糖尿病微血管病变的早期诊断和病情分析有重要的临床价值。
To observe the changes of plasma ET-1, GMP-140, tissue plasminogen activator (tPA) and their inhibitors PAI-1) changes. Methods: The expressions of ET-1, GMP-140 and TGF-β1 in 20 normal subjects and 40 patients with type 2 diabetes mellitus (22 without microangiopathy and 18 with microangiopathy) Changes in tPA and PAI-1. Results: The levels of ET-1, GMP-140 and PAI-1 in diabetic patients were significantly higher than those in normal controls and tPA was significantly lower than those in patients without microangiopathy. The changes of ET-1 and GMP- 140, PAI-1 was significantly positive correlation, but negative correlation with tPA. Conclusion: The above determination of some related molecular markers of prethrombotic state has important clinical value in the early diagnosis and condition analysis of diabetic microangiopathy.