1 引言已知多种药物能引起血小板量和质的改变而发生出血倾向。近年来,常有肝素引起血小板减少,可伴有血栓形成,甚可无血小板减少而有血栓形成的报告。抗凝药肝素为治疗和预防静脉血栓形成有效的药物。在用药过程中发生出血,多归咎为肝素过量;有血栓形成又多认为系肝素用量不足,可招致不良后果。本文简要复习肝素——血小 1 Introduction It is known that a variety of drugs can cause changes in platelet mass and quality of bleeding tendency. In recent years, heparin often lead to thrombocytopenia, may be associated with thrombosis, thrombocytopenia can even have thrombosis report. Anticoagulant heparin is an effective drug for the treatment and prevention of venous thrombosis. In the course of bleeding medication, ascribed to excessive heparin; thrombosis and more thought that the amount of heparin, can lead to adverse consequences. This article briefly reviews heparin - small blood