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目的研究脂蛋白 -α( LP-α)和 C-反应蛋白 ( CRP)在脑梗死患者中的变化。方法采用透射比浊法分别在急性期和恢复期检测 3 6例脑梗死患者的血清 LP-α和 CRP含量 ,并与 3 2例正常人进行对照。结果 1与正常对照组比较 ,脑梗死组 L P-α两次结果均有显著差异 ( P<0 .0 5 ) ,脑梗死急性期与恢复期 L P-α无显著性差异 ( P>0 .0 5 )。 2与正常对照组比较 ,脑梗死组急性期 CRP有显著差异( P<0 .0 5 ) ,而脑梗死恢复期 CRP无显著差异 ( P>0 .0 5 )。结论 LP-α与 CRP同样可作为脑梗死的观察指标 ,L P-α水平不受病程及治疗影响。因此 ,急性期检测结果可说明患者 LP-α水平是脑梗死独立危险因素。但 CRP作为急性期反应蛋白 ,随病程转归而恢复正常水平。脑梗死是炎症参与的复杂病理过程。
Objective To study the changes of LP-α and C-reactive protein (CRP) in patients with cerebral infarction. Methods The levels of LP-α and CRP in 36 patients with cerebral infarction were detected by transmission turbidimetry in acute phase and convalescent phase, respectively, and compared with 32 healthy controls. Results 1 Compared with the normal control group, the results of L P-α in cerebral infarction group had significant difference (P <0.05), but there was no significant difference between the acute and convalescent phase of cerebral infarction (P> 0) .0 5). Compared with the normal control group, the CRP in acute cerebral infarction group was significantly different (P <0.05), while there was no significant difference in CRP recovery during cerebral infarction (P> 0.05). Conclusions LP-α and CRP can be used as an index of cerebral infarction. The level of L P-α is not affected by the course of disease and treatment. Therefore, the acute phase test results may indicate that patients with LP-α level is an independent risk factor for cerebral infarction. However, CRP as an acute phase reaction protein, with the return of normal course of disease. Cerebral infarction is a complex pathological process involved in inflammation.