论文部分内容阅读
目的 探讨脉压、胰岛素抵抗在高血压、高血压合并大血管病变中的作用。方法 对 31例正常对照者、36例单纯高血压患者、4 0例高血压合并大血管病变患者测量血压、脉压 ,测定空腹血糖(FPG) ,胰岛素 (FINS) ,计算胰岛素抵抗指数 (IR =FPG FINS/ 2 2 .5 )。结果 高血压合并大血管病变组与单纯高血压组和对照组比较 ,脉压在高血压合并大血管病变组最高 (P分别 <0 0 1和 <0 0 5 )。虽然单纯高血压组和高血压合并大血管病变组IR高于对照组 (P <0 0 5 ) ,但IR在高血压二组间无显著性差异。结论 在高血压病人出现大血管病变过程中 ,脉压的作用要强于胰岛素抵抗。因此 ,降压治疗时应注意脉压的变化。
Objective To investigate the role of pulse pressure and insulin resistance in hypertension and hypertension with macrovascular complications. Methods Blood pressure, pulse pressure, fasting blood glucose (FPG) and insulin (FINS) were measured in 31 normal controls, 36 hypertensive patients and 40 hypertensive patients with macrovascular complications. The insulin resistance index (IR = FPG FINS / 2 2 .5). Results Compared with simple hypertensive group and control group, the pulse pressure was the highest in hypertensive patients with macroangiopathy (P <0.01 and <0.05). Although IR in hypertensive group and hypertensive group with macrovascular disease was higher than that in control group (P <0.05), IR had no significant difference between the two groups. Conclusion In the process of macroangiopathy in hypertensive patients, the effect of pulse pressure is stronger than that of insulin resistance. Therefore, antihypertensive treatment should pay attention to changes in pulse pressure.