目的探讨提高新生儿缺氧缺血性脑病（ＨＩＥ）疗效。方法将１９９１～１９９８年住院足月ＨＩＥ患儿１７７例分为两组，治疗组８８例系１９９４～１９９８年住院患者，静注负荷量苯巴比妥（Ｐｎｅｎｏｂａｒｂｉｔａｌ．ＰＢ），２～６小时后加用利多卡因（Ｌｉｄｏｃａｉｎｅ）负荷量静注。对照组８９例系１９９１～１９９３年住院患者，单用ＰＢ负荷量静注。结果治疗组治愈率７７３％，惊厥昏迷时间明显缩短。对照组治愈率６０７％。两组比较，经统计学处理有显著意义（Ｐ＜００５）。结论ＰＢ与利多卡因联合治疗ＨＩＥ疗效较好。 Objective To explore the effect of improving neonatal hypoxic-ischemic encephalopathy (HIE). Methods A total of 177 hospitalized HIE infants aged from 1991 to 1998 were divided into two groups. 88 patients in the treatment group were hospitalized from 1994 to 1998 with intravenous infusion of Pnenobarbital (PBP). After 2 to 6 hours, Add lidocaine (Lidocaine) intravenously. In the control group, 89 cases were inpatients from 1991 to 1993, and were treated with PB loading alone. Results The cure rate of the treatment group was 773%, and the convulsion coma time was significantly shortened. The cure rate of the control group was 60.7%. The two groups were statistically significant (P <005). Conclusion The combination of PB and lidocaine in HIE is better.