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目的:探讨高胰岛素血症、胰岛素抵抗、高血脂和肥胖与老年高血压之间的关系;方法:对无糖尿病病史的老年原发性高血压患者100例,老年对照组50例的空腹血糖及餐后2小时血糖、胰岛素、C肽、血脂、体重指数和胰岛素敏感指数进行对照分析对比;结果:空腹胰岛素,高血压组为14.2±6.0uIU/L,对照组为7.4±5.7uIU/L((P<0.001),高血压组有明显的高胰岛素血症,其胰岛素敏感性指数显著(P<0.001),血清甘油三脂明显增高和apoA1明显下降(P<0.05)肥胖者占74%;结论:老年高血压患者多伴有糖代谢和脂蛋白代谢异常,胰岛素抵抗所产生的高胰岛素血症为其基本的代谢异常。
Objective: To investigate the relationship between hyperinsulinemia, insulin resistance, hyperlipidemia and obesity and senile hypertension.Methods: 100 cases of senile essential hypertension with no history of diabetes mellitus and 50 cases of senile control group had fasting blood glucose The fasting insulin and hypertension group were 14.2 ± 6.0uIU / L and the control group was 7.4 ± 5.7uIU / L (P <0.05) .Conclusion: The fasting blood glucose, insulin, C peptide, blood lipid, body mass index and insulin sensitivity index were compared and analyzed. (P <0.001). Hypertension group had obvious hyperinsulinemia with a significant insulin sensitivity index (P <0.001), serum triglyceride was significantly increased and apoA1 was significantly decreased (P <0.05). Conclusion: Elderly patients with hypertension are often accompanied by abnormal glucose metabolism and lipoprotein metabolism, insulin resistance produced by hyperinsulinemia as its basic metabolic abnormalities.