Objective: To investigate the expressions and the clinical significance of P53, C-erbB-2 and vascular endothelial growth factor (VEGF) in non-small cell lung cancer (NSCLC). Methods: 121 specimens of NSCLC were examined for P53, C-erbB-2 and VEGF by immunohistochemical staining. Results: The positive rates of P53, C-erbB-2 and VEGF in the carci- nomatous tissue were 43%, 39% and 31% respectively. P53 gene protein expression in lung cancer was significantly related to histological type and P-TNM staging of lung cancer patients (P < 0.05), and was not associated with the sex, age, the size of primary cancer, lymph node metastasis and cell differentiation (P > 0.05). C-erbB-2 gene protein expression in lung cancer was closely related to histological type and cell differentiation (P < 0.05), and was not associated with the sex, age, the size of primary cancer, lymph node metastasis and P-TNM staging of lung cancer patients (P > 0.05). VEGF in lung cancer was only closely related to cell differentiation (P < 0.05), and was not associated with the sex, age, the size of primary cancer, lymph node metastasis, histological type and P-TNM staging of lung cancer patients (P > 0.05). Conclusion: It is possible for P53, C-erbB-2 and VEGF to play an important role in the oncogenesis and development of non-small cell lung cancer. Objective: To investigate the expressions and the clinical significance of P53, C- erbB-2 and vascular endothelial growth factor (VEGF) in non-small cell lung cancer (NSCLC). Methods: 121 specimens of NSCLC were examined for P53, C- Results: The positive rates of P53, C-erbB-2 and VEGF in the carci- nomatous tissue were 43%, 39% and 31% respectively. P53 gene protein expression in lung cancer was significantly related to histological type and P-TNM staging of lung cancer patients (P <0.05), and was not associated with the sex, age, the size of primary cancer, lymph node metastasis and cell differentiation (P> 0.05). C-erbB -2 gene protein expression in lung cancer was closely related to histological type and cell differentiation (P <0.05), and was not associated with the sex, age, the size of primary cancer, lymph node metastasis and P-TNM staging of lung cancer patients (P> 0.05). VEGF in lung cancer was only closely related to cell di (P <0.05), and was not associated with the sex, age, the size of primary cancer, lymph node metastasis, histological type and P-TNM staging of lung cancer patients (P> 0.05). Conclusion: It is possible for P53, C-erbB-2 and VEGF to play an important role in the oncogenesis and development of non-small cell lung cancer.