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力可拉明与加兰他明系由紫花石蒜及臭水仙中提得,本文报导了它们的碘甲烷盐对胆碱反应系统的影响.力可拉明与加兰他明静脉注射于家兔及猫引起血压下降、肠张力及蠕动加强,可为阿托品对抗.其0.5％的溶液不同程度地收缩家兔的瞳孔.较高浓度的加兰他明(1×10~(-6)克/毫升)与力可拉明(1×10~(-5)克/毫升)可使离体豚鼠迴肠收缩,较低浓度加强乙酰胆碱、氯化钡与组织胺对肠段的收缩作用,对M-胆碱反应系统的作用加兰他明比力可拉明大5-10倍.在水蛭背肌及蛙腹直肌标本上,证明加兰他明加强乙酰胆碱的作用稍大于力可拉明.在猫与大白鼠的试验证明该二药加强了刺激神经所致的腓肠肌收缩作用,对大白鼠坐骨神经-腓肠肌标本的作用与刺激频率及剂量有关,高频(25-100次/秒)和大剂量引起肌缩抑制者较多,而低频(5-10次/秒)和小剂量绝大多数引起肌缩加强.加兰他明比力可拉明作用约大5倍.如预先用阿托品处理,大量乙酰胆碱引起的肌缩抑制,加兰他明与力可拉明均可使之加强.加兰他明、力可拉明和新斯的明可对抗箭毒所引起的肌肉松弛,但对琥珀酰胆碱则反加重.加兰他明与力可拉明类似新斯的明能对抗TEA,C6所致的神经节阻断,亦能加强电刺激交感节前纤维所致的瞬膜收缩.力可拉明的中枢M-与N-胆碱反应系统的兴奋作用较明显,而加兰他明则较弱.静脉注射加兰他明、力可拉明与新斯的明对小白鼠的LD_(50)分别为0.958,16.65,0.174毫克/公斤,中毒症状为流涎、震颤、抽搐,动物死于呼吸麻痹.
Levocablam and galantamine are derived from the genus Lycoris and Stinky, and their effects on the cholinergic system are reported in this article. Lecamine and galantamine are injected intravenously into the home Rabbits and cats caused a decrease in blood pressure, increased intestinal tension and peristalsis, which was antagonistic to atropine, and 0.5% of the solution constricted rabbit pupils to varying degrees. Higher concentrations of galantamine (1 × 10 -6 grams) / Ml) and force of kalalamin (1 × 10 -5 (5) g / ml) isolated guinea pig ileum can be contracted, lower concentrations of acetylcholine, barium chloride and histamine contraction of intestinal segments of the role of Effect of M-choline reaction system Galantamine is 5-10 times more potent than clonazepam, demonstrating that the effect of galantamine on enhancing acetylcholine is slightly greater than that of forcecolamin In the cat and rat experiments prove that the two drugs to enhance the stimulation of nerve-induced gastrocnemius contraction, the rat sciatic nerve - gastrocnemius specimens and stimulation frequency and dose-related, high frequency (25-100 times / sec) and High dose caused more muscle suppression, and low frequency (5-10 times / second) and the small dose of the vast majority caused by muscle contraction. Galantamine ratio The role of calamine about 5 times as large as pretreatment with atropine, a large number of acetylcholine-induced inhibition of muscle contraction, both galantamine and power may be able to make it stronger .Lineramine, Ming against arrow poisoning caused by muscle relaxation, but the anti-succinylcholine is anti-emptive .Galantamine and the power of ciclamino-similar neostigmine against TEA, C6-induced ganglion block, but also To strengthen the electrical stimulation of sympathetic preganglionic fibrillation caused by instantaneous membrane contraction.Riclamin’s central M- and N-choline reaction system excitatory effect is more obvious, while galantamine is weaker intravenous galantamine , LD50 of levoflozin and neostigmine were 0.958, 16.65 and 0.174 mg / kg respectively. Symptoms were salivation, tremor and convulsion, and the animals died of respiratory paralysis.