氨苯砜用于皮肤科临床,经30多年的实践,至今仍保持它优异的治疗价值。为了进一步了解其药理作用、疗愈机制、适应症、副作用以及其新进展,以便正确使用并扩大使用范围。现复习有关文献如下。化学性质和吸收与排泄氨苯砜(4-4′diaminodiphenylsulfone,DDS)是砜类药的母体。其它砜类药入体后一般均转成 DDS 而发挥作用。DDS 溶于甲醇、丙酮、醋酸乙酯、苯和稀盐酸,但不溶于水。口服后由小肠吸收入血,一部分从淋 Dapsone for dermatology clinical, after 30 years of practice, still maintain its excellent therapeutic value. In order to further understand its pharmacological effects, mechanisms of treatment, indications, side effects and its new progress in order to correctly use and expand the scope of use. Now review the relevant literature is as follows. Chemical properties and absorption and excretion Dapsone (4-4’diaminodiphenylsulfone, DDS) is the precursor of sulfone drugs. Other sulfone drugs into the body are generally converted into DDS and play a role. DDS soluble in methanol, acetone, ethyl acetate, benzene and dilute hydrochloric acid, but not soluble in water. After oral absorption into the blood by the small intestine, part from the shower