含化复方新诺明引起过敏性休克一例患者，女，３０岁，因咽峡炎于１９９２年８月７日晚１０时自行含化复方新诺明（广州白云山制药厂）两片、约７分钟后，出现全身搔痒，当即肌注苯海拉明２０ｍｇ，静推１０％葡萄糖酸钙１０ｍｌ，旋即全身泛起荨麻疹，奇痒难忍，眼睑轻度水肿，嘴唇发麻，咽部“发紧”，发音困难，烦躁，立即给予吸氧，静推地塞米松１０ｍｇ，皮下注射肾上腺素０．５ｍｇ，与此同时，患者脸色苍白、鼻尖、未梢发凉，口唇紫绀，时吸暂停，意识丧失，脉搏１４０次／分，细数，血压测不到，再次给予皮下注射肾上腺素０．５ｍｇ，静点地塞米松１５ｍｇ，并给予扩容、纠酸，约一分钟后，欲行气管切开时，患者呼吸渐恢复、继而意识清楚，紫绀减轻，血压１０／１６ｋＰａ，遂休克纠正。复方新诺明片致过敏性休克者尚属少见，该患者有青霉素过敏史，局部用药又易致过敏，考虑喉头痉挛与药物含化有关。（长治市人民医院王爱军，崔文华，郭天然）含化复方新诺明引起过敏性休克一例@王爱军，崔文华，郭天然$长治市人民医院 A patient with anaphylactic shock containing cotrimoxazole, female, 30 years of age, due to angina in August 7, 1992 at 10 o’clock on the evening of self-compound cotrimoxazole (Guangzhou Baiyunshan Pharmaceutical Factory) two, about 7 minutes later, there systemic itching, immediate intramuscular diphenhydramine 20mg, static push 10% calcium gluconate 10ml, immediately systemic urticaria, itchy, eyelid edema, numbness lips, pharynx “ Tight, ”dysphonia, irritability, immediately give oxygen, intravenous dexamethasone 10mg, subcutaneous epinephrine 0.5mg, at the same time, the patient pale, nose tipless hair, lips cyanosis, when suspended , Loss of consciousness, pulse 140 beats / min, breakdown, blood pressure can not be measured, again given subcutaneous injection of epinephrine 0.5mg, intravenous dexamethasone 15mg, and give expansion, correct acid, about a minute later, When incised, the patient’s breathing gradually recovered, and then conscious, cyanotic relief, blood pressure 10 / 16kPa, then shock corrected. Cotrimoxazole induced allergic shock is still rare, the patient has a history of penicillin allergy, topical and easy to cause allergies, consider the laryngeal spasm and drug-related. (Changzhi City People’s Hospital Wang Aijun, Cui Wenhua, Guo natural) containing cotrimoxazole induced anaphylactic shock @ Wang Aijun, Cui Wenhua, Guo natural $ Changzhi City People’s Hospital